General
Preferred name
Kaempherol
Synonyms
KAEMPFEROL ()
Kempferol ()
Robigenin ()
Kaempferol hydrate ()
Kaempferol (NSC 407289) ()
Ci 75640 ()
Populnetin ()
3'-deoxyquercetin ()
Nimbecetin ()
Pelargidenolon 1497 ()
Rhamnolutin ()
Pelargidenon ()
Trifolitin ()
NSC-407289 ()
Pelargidenolon ()
Indigo yellow ()
Rhamnolutein ()
C.i. 75640 ()
Kampcetin ()
NSC-656277 ()
Swartziol ()
Kaempferol ()
P&D ID
PD000231
CAS
520-18-3
Tags
available
drug candidate
natural product
nuisance
Drug indication
Discovery agent
Sexual dysfunction
Drug Status
experimental
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Kaempferol is a flavonol, a type of flavonoid, naturally occuring in a variety of plants. It has antibacterial activity against Gram-negative Helicobacter pylori and is reported to inhibit H. pylori HsrA (homeostatic stress regulator) . (GtoPdb)
DESCRIPTION Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor ¦Á expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer[1][2][3][4].
PRICE 29
DESCRIPTION Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERR?? and ERR??. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
DESCRIPTION Inhibits complex I of the mitochondrial electron transport chain (Tocris Bioactive Compound Library)
DESCRIPTION Mitochondrial Ca2+ uniporter (MCU) activator; proapoptotic (Tocriscreen Total)
DESCRIPTION Kaempferol, a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells. It also inhibits Beta-secretase 1. (Enamine Bioactive Compounds)
DESCRIPTION Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities. (TargetMol Bioactive Compound Library)
Cell lines
12
Organisms
11
Compound Sets
19
AdooQ Bioactive Compound Library
A10495
Cayman Chemical Bioactives
11852
ChEMBL Drugs
CHEMBL150
Concise Guide to Pharmacology 2021/22
11052
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01852
DrugMAP
DMHEMUB
Enamine Bioactive Compounds
EBC-44279
EU-OPENSCREEN Bioactive Compound Library
EOS100804
Guide to Pharmacology
11052
MedChem Express Bioactive Compound Library
HY-14590
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
Kaempferol
TargetMol Bioactive Compound Library
T2177
The Spectrum Collection
Tocris Bioactive Compound Library
3603
Tocriscreen Total
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
286.05
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
2.28
TPSA
111.13
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
3
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Nonspecific/NOS
Flavonoid
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Apoptosis Inducers
Target
AKR1B1, ALOX15B, ALOX5, AR, CYP1B1, GLO1, HSD17B1, UGT3A1
Endogenous Metabolite
Estrogen Receptor/ERR
HIV
Mitophagy
Parasite
Estrogen/progestogen Receptor,Fatty Acid Synthase
ER
MOA
bone resorption inhibitor, estrogen-related receptor inverse agonist
Pathway
Apoptosis
Autophagy
Endocrinology/Hormones
Metabolism
Microbiology/virology
Proteases/Proteasome
Anti-infection
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Source data