General
Preferred name
METHIMAZOLE
Synonyms
Tapazole ()
thiamazole ()
Tapazole, Thiamazole ()
Tiamazol ()
NSC-38608 ()
Mercaptizole ()
Thiamazol ()
Favistan ()
Methimazole-d3 ()
P&D ID
PD000229
CAS
60-56-0
1160932-07-9
Tags
available
drug
Approved by
FDA
First approval
1950
Drug indication
Thyroid Inhibitor
Hyperthyroidism
Drug Status
approved
vet_approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Methimazole is a thioamide antithyroid drug which acts as a thyroperoxidase inhibitor and reduces serum CXCL10 (a chemokine that participates in the self-perpetuation of the inflammatory processes in patients with autoimmune thyroid disease) from thyrocytes . (GtoPdb)
DESCRIPTION Methimazole (also known as Tapazole or Thiamazole or MMI) is an antithyroid drug,and part of the thioamide group. Like its counterpart propylthiouracil, a major side effect of treatment is agranulocytosis. (BOC Sciences Bioactive Compounds)
Compound Sets
29
BOC Sciences Bioactive Compounds
methimazole-cas-60-56-0-item-84-291131
Cayman Chemical Bioactives
23718
33278
ChEMBL Approved Drugs
CHEMBL1515
ChEMBL Drugs
CHEMBL1515
Concise Guide to Pharmacology 2017/18
6649
Concise Guide to Pharmacology 2019/20
6649
Concise Guide to Pharmacology 2021/22
6649
Concise Guide to Pharmacology 2023/24
6649
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00763
DrugBank Approved Drugs
DB00763
DrugCentral
1745
DrugCentral Approved Drugs
1745
DrugMAP
DM25FL8
DrugMAP Approved Drugs
DM25FL8
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
6649
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1515
MedChem Express Bioactive Compound Library
HY-B0208
NCATS Inxight Approved Drugs
554Z48XN5E
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Methimazole(Tapazole)
TargetMol Bioactive Compound Library
T0840
The Spectrum Collection
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
114.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
1
Aromatic Ring Count
1
cLogP
1.08
TPSA
20.72
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
5.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
Target
Thyroid peripheral conversion
TPO
Indication
hyperthyroidism
MOA
antithyroid agent
Therapeutic Class
Antithyroid Agents
Source data