General
Preferred name
PIRIBEDIL
Synonyms
PIRIBEDIL HYDROCHLORIDE ()
Piribedil maleate ()
Piribedil D8 ()
ET-495 D8 ()
Trivastal ()
Trivastan ()
ET-495 ()
EU-4200 ()
Piribedil dihydrochloride ()
Trivastal, Trivastan ()
Trivastal LP ()
PIRIBEDIL ()
P&D ID
PD000220
CAS
3605-01-4
1451048-94-4
78213-63-5
Tags
natural product
drug
available
Drug indication
Discovery agent
Drug Status
investigational
approved
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
5-HT1B agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Non-selective dopamine receptor agonist
(LOPAC library)
DESCRIPTION
Dopamine agonist
(Tocriscreen Total)
DESCRIPTION
Piribedil dihydrochloride is a dopamine receptor agonist that is selective for the D3 subtype, for which it has 20 times higher affinity than for D2, and possesses no significant affinity for D1 receptors.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
27
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
Ki Database
LOPAC library
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
55
Molecular Weight
298.14
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
1.53
TPSA
50.72
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D3
Target
Dopamine Receptor
Adrenergic Receptor
??2-adrenergic
D2
D3 receptor,adrenoceptor ??2,D2 receptor
ADRA1A, ADRA2A, ADRA2C, DRD2, DRD3, DRD4, HTR1A, HTR2B
DA agonist
Histone methyltransferase
Adrenergic Receptor,Dopamine Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Epigenetics
Primary Target
Non-selective Dopamine
MOA
Agonist
Dopamine D2 Agonists
Dopamine D3 Agonists
alpha2-Adrenoceptor Antagonists
Dopamine Receptor agonist
Member status
member
Indication
Parkinson's Disease, dizziness
Source data
