General
Preferred name
TIRATRICOL
Synonyms
Triac ()
4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodobenzeneacetic acid ()
3,3',5-Triiodothyroacetic acid ()
Tiratricol, 3,3',5-triiodothyroacetic acid ()
"Tiratricol, 3,3',5-triiodothyroacetic acid" ()
triiodothyroacetic acid ()
3,5,3'-TRIIODOTHYROACETATE ()
NSC-759294 ()
TIRACANA ()
T3-ACETIC ACID ()
LEVOTHYROXINE SODIUM IMPURITY, TRIIODOTHYROACETIC ACID, OR T3-ACETIC ACID- ()
P&D ID
PD000215
CAS
51-24-1
Tags
available
drug
Drug indication
Wound healing
Drug Status
investigational
approved
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tiratricol is a thyroid hormone analogue.
(GtoPdb)
PRICE
29
DESCRIPTION
Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC50s of 20 ¦ÌM and 32 ¦ÌM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus). It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication.[2].
DESCRIPTION
Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
20
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
NURSA ligand set
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
621.76
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
4.63
TPSA
66.76
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
THR
thyroid hormone
THRA, THRB
Flavivirus
Thyroid hormone receptor
TNF Receptor
Indication
Refetoff syndrome
MOA
thyroid hormone stimulant
Pathway
Endocrinology/Hormones
Anti-infection
Apoptosis
Vitamin D Related/Nuclear Receptor
Recommended Cell Concentration
1 uM
Source data
