General
Preferred name
TROLOX
Synonyms
P&D ID
PD000212
CAS
53188-07-1
56305-04-5
Tags
available
nuisance
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage[1][2].
PRICE
29
DESCRIPTION
Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. It is effective as adjunctive therapy in the treatment of certain cancers. It shows anti-inflammatory activity against COX-1 (IC50= 0.13µM), COX-2 ( IC50= 0.15µM).
(Enamine Bioactive Compounds)
DESCRIPTION
Trolox is a vitamin E analogue, used in reducing oxidative stress or damage.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
5
Organisms
2
Compound Sets
11
A Collection of Useful Nuisance Compounds (CONS) for Interrogation of Bioassay Integrity
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
Nuisance compounds in cellular assays
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
250.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
2.49
TPSA
66.76
Fraction CSP3
0.5
Chiral centers
1.0
Largest ring
6.0
QED
0.8
Structural alerts
1
Singlet oxygen quenching
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
Metabolism
oxidation-reduction
Target
antioxidant
Apoptosis
Ferroptosis
Reactive Oxygen Species
Vitamin
Reactive Oxygen Species (ROS)
Nuisance MOA
Singlet oxygen quenching
Targets
Cyclooxygenase-1
Cyclooxygenase-2
Source data
