General
Preferred name
PENTETIC ACID
Synonyms
Gadopentetic acid ()
Diethylenetriaminepentaacetic acid ()
DTPA ()
Acidum penteticum ()
Detapac ()
Detarex ()
PENTETATE CALCIUM TRISODIUM ()
PENTETATE ZINC TRISODIUM ()
DTP-A ()
NSC-7340 ()
Pentetate ()
Kelazin ()
Zinc-dtpa ()
Zinc trisodium pentetate ()
Trisodium zinc dtpa ()
Calcium trisodium dtpa ()
NSC-34249 ()
Calcium Trisodium Pentetate ()
P&D ID
PD000202
CAS
67-43-6
12111-24-9
11082-38-5
13407-13-1
1004765-76-7
Tags
natural product
drug
available
Approved by
FDA
Drug Status
approved
Max Phase
Phase 4
Drug indication
Chelating Agent (plutonium),Diagnostic Aid
Chelating Agent (plutonium)
First approval
2004
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION
DTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides.[A32501] It is FDA approved for the treatment of individuals with known or suspected internal contamination with plutonium, americium or curium to increase the rates of elimination.[L2243]; ; Due to the pharmacokinetic elimination by the kidneys, pentetic acid conjugated with technetium Tc-99m is being used clinically to estimate physiological parameters such as glomerular filtration rat and effective renal plasma flow.[T168]
DESCRIPTION
Zinc-dependent proteases carboxypeptidase A and aminopeptidase N inhibitor; chelating agent
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
0
Compound Sets
18
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
72
Molecular Weight
393.14
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
5
Rotatable Bonds
16
Ring Count
0
Aromatic Ring Count
0
cLogP
-2.68
TPSA
196.22
Fraction CSP3
0.64
Chiral centers
0.0
Largest ring
0.0
QED
0.18
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Zn2+-dependent protease
Target
chelating agent
Member status
virtual
MOA
Nitric Oxide Scavengers
Source data
