General
Preferred name
SULFADOXINE
Synonyms
Sulphadoxine ()
Fansimef-sulfadoxine ()
Sulfadoxin ()
Sulphormethoxine ()
Ro-44393 ()
Sulfadoxinum ()
Sulfadoxine component of fansidar ()
RO 4-4393 ()
Fanasulf ()
Sulforthamidine ()
NSC-759319 ()
WR-4073 ()
J21.373J ()
RO-4-4393 ()
Sulfadoxin ()
Sulfadoxina ()
Sufadoxine ()
Sulfadoxin-d4 ()
P&D ID
PD000200
CAS
2447-57-6
1330266-05-1
Tags
available
drug
Approved by
FDA
First approval
1981
Drug indication
Malaria
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Sulfadoxine is a sulfonamide antimalarial compound.

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
INDICATION Sulfadoxine is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well.; Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected.
DESCRIPTION Sulfadoxine is a sulfonamide containing compound with antimalarial activity. It is used in the treatment of malaria as a combination therapy.

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
DESCRIPTION Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.
PRICE 29
DESCRIPTION Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase. It is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections. (Enamine Bioactive Compounds)
DESCRIPTION Sulfadoxine (Sulphadoxine) is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial properties. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
24
Cayman Chemical Bioactives
21488
37200
ChEMBL Approved Drugs
CHEMBL1539
ChEMBL Drugs
CHEMBL1539
Drug Repurposing Hub
DrugBank
DB01299
DrugBank Approved Drugs
DB01299
DrugCentral
2503
DrugCentral Approved Drugs
2503
DrugMAP
DMZI2UF
DrugMAP Approved Drugs
DMZI2UF
DrugMatrix
Enamine Bioactive Compounds
EBC-03788
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100863
Guide to Pharmacology
10173
MedChem Express Bioactive Compound Library
HY-B0439
Natural product-based probes and drugs
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Sulfadoxine(Sulphadoxine)
TargetMol Bioactive Compound Library
T0836
The Spectrum Collection
Withdrawn 2.0
521
External IDs
43
Properties
(calculated by RDKit )
Molecular Weight
310.07
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
0.88
TPSA
116.43
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Autophagy
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Metabolism
Microbiology/virology
Proteases/Proteasome
Anti-infection
Metabolic Enzyme/Protease
Indication
malaria
MOA
dihydropteroate synthase inhibitor
ATC
J01EQ13
Biosynthetic Origin
Alkaloid, Other (Shikimate)
Therapeutic Indication
Antiparasitic
Therapeutic Class
Antimicrobial
Target
antibiotic
Endogenous Metabolite
HIV
Parasite
DHFR
DHPS
Source data