General
Preferred name
CARGLUMIC ACID
Synonyms
N-carbamylglutamate ()
N-Carbamyl-L-Glutamic Acid ()
Carbamylglutamic acid ()
Carbamino-L-glutamic acid ()
Ureidoglutaric acid ()
Carbaglu ()
Carbamylglutamic acid, Carbamino-L-glutamic acid, Ureidoglutaric acid, N-Carbamylglutamate ()
OE-312 ()
OE 312 ()
NSC-760124 ()
OE 312 (LABORATORY CODE DESIGNATION) ()
P&D ID
PD000184
CAS
1188-38-1
Tags
natural product
drug
available
Approved by
FDA
First approval
2010
Drug Status
approved
Drug indication
Acute hyperammonaemia
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Carglumic acid is an orphan drug.
(GtoPdb)
PHARMACODYNAMICS
The median Tmax of Carbaglu was 3 hours (range: 2-4). The daily dose of carglumic acid ranges from 100 to 250 mg/kg and this does are normally adjusted to maintain normal plasma levels of ammonia.
ABSORPTION
30% bioavailability;; Cmax, mean, 100 mg/kg dose = 2.6 μg/mL (range of 1.9 - 4.8) ; Carglumic acid is not subject to to intracellular degradation.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
23
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
190.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
4
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.03
TPSA
129.72
Fraction CSP3
0.5
Chiral centers
1.0
Largest ring
0.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
carbamoyl-phosphate synthase activator
Carbamoyl Phosphate Synthetase 1 (CPS1) Activators
carbamoyl phosphate synthase activator
Target
Carbamoyl-phosphate synthase [ammonia], mitochondrial
Carbamoyl-phosphate synthase
CPS1
CPSase
Member status
member
Indication
hyperammonemia
Biosynthetic Origin
Other (Amino Acid)
Therapeutic Indication
Hyperammonemia
Therapeutic Class
Metabolic Disorders
Source data
