General
Preferred name
NIKETHAMIDE
Synonyms
Theramune ()
N,N-Diethylnicotinamide ()
NSC-130820 ()
Niquetamida ()
Coramine ()
Nikethyl ()
Nicethamide ()
Carditonic ()
P&D ID
PD000180
CAS
59-26-7
Tags
available
drug
Drug Status
approved
withdrawn
experimental
investigational
Max Phase
2.0
Drug indication
respiratory system disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Nikethamide is a stimulant which mainly influences the respiratory cycle. Widely known by its former sales name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overtreatments, before the advent of endotracheal intubation and positive-pressure lung expansion. It is now thought to be of no value for such purposes, and may be dangerous.
Compound Sets
12
ChEMBL Drugs
CHEMBL2104607
Drug Repurposing Hub
DrugBank
DB13655
DrugCentral
3383
DrugCentral Approved Drugs
3383
DrugMatrix
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-B1280
NPC Screening Collection
ReFrame library
The Spectrum Collection
Withdrawn 2.0
w247
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
178.11
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
1.56
TPSA
33.2
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
immunostimulant
ATC
R07AB02
R07AB52
Toxicity type
neurological
Source data