General
Preferred name
GUAIACOL
Synonyms
Pcg (combination) ()
O-methylcatechol ()
2-Hydroxyanisole ()
O-Methoxyphenol ()
2-Methoxyphenol ()
Sulfogaiacol ()
o-methoxyphenol, 2-hydroxyanisole, O-methylcatechol ()
O-guaiacol ()
(mu)-methoxyphenol ()
Pyroguaiac acid ()
Guaiastil ()
O-hydroxyanisole ()
NSC-3815 ()
FEMA NO. 2532 ()
Creodon ()
P&D ID
PD000172
CAS
90-05-1
8021-39-4
26638-03-9
1321-14-8
Tags
available
drug
Approved by
FDA
Drug Status
approved
investigational
Max Phase
3.0
Drug indication
Cough
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-¦ÊB activation[1]. Anti-inflammatory activity[1].
PRICE
29
DESCRIPTION
Sulfogaiacol is a cough suppressant with expectorant properties, and it can be used for research on acute respiratory infections with oral activity[1][2].
DESCRIPTION
Guaiacol is an agent thought to have disinfectant properties and used as an expectorant.
(Enamine Bioactive Compounds)
DESCRIPTION
Guaiacol (2-Methoxyphenol) is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic. It also can be used as an indicator in chemical reactions that produce oxygen. When oxygen binds to it, the complex turns yellowish brown and absorbs light maximally at about 470 nm.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
18
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Enamine Bioactive Compounds
Enamine BioReference Compounds
LSP-MoA library (Laboratory of Systems Pharmacology)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
58
Molecular Weight
124.05
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
1.4
TPSA
29.46
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
Immunology/Inflammation
Metabolism
Neuroscience
Anti-infection
Metabolic Enzyme/Protease
Target
COX
Endogenous Metabolite
NF-κB
NF-??
CA2
Bacterial
COX,NF-¦ÊB
MOA
Antibiotic inhibitor
local anesthetic
Indication
cough suppressant
Source data
