General
Preferred name
HYMECROMONE
Synonyms
HYMECHROME ()
Cantabiline ()
4-MU ()
4-Methylumbelliferone ()
4-Methylumbelliferone (4-MU) ()
NSC-9408 ()
NSC-19026 ()
LM-94 ()
Himecromona ()
P&D ID
PD000163
CAS
90-33-5
56275-29-7
Tags
available
drug
Drug Status
approved
experimental
investigational
Max Phase
2.0
Drug indication
respiratory system disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 4-Methylumbelliferone is a hyaluronic acid biosynthesis inhibitor with antitumoral and antimetastatic effects.
PRICE 29
DESCRIPTION 4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM, used as choleretic and antispasmodic drugs and as a standard for the fluorometric determination of enzyme activity. (BOC Sciences Bioactive Compounds)
DESCRIPTION 4-Methylumbelliferone is a hyaluronic acid biosynthesis inhibitor with antitumoral and antimetastatic effects. It also selectively inhibits human carbonic anhydrase IX and XII with KI of 32.1 and 5.8 nM, respectively. 4-Methylumbelliferone also inhibits testosterone 17-beta-dehydrogenase 3 and estradiol 17-beta-dehydrogenase, IC50=0.9µM. (Enamine Bioactive Compounds)
DESCRIPTION 4-Methylumbelliferone (Hymecromone) is a coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID. (TargetMol Bioactive Compound Library)
Cell lines
4
Organisms
0
Compound Sets
19
AdooQ Bioactive Compound Library
A10015
BOC Sciences Bioactive Compounds
4-methylumbelliferone-cas-90-33-5-item-84-79322
Cayman Chemical Bioactives
29603
ChEMBL Drugs
CHEMBL12208
Drug Repurposing Hub
DrugBank
DB07118
DrugCentral
1401
DrugCentral Approved Drugs
1401
DrugMatrix
Enamine Bioactive Compounds
EBC-13723
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100832
MedChem Express Bioactive Compound Library
HY-N0187
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
4-Methylumbelliferone(4-MU)
TargetMol Bioactive Compound Library
T1391
The Spectrum Collection
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
176.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
1.81
TPSA
50.44
Fraction CSP3
0.1
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
hyaluronic acid (HA) synthesis
MAOA, MAOB
MOA
monoamine oxidase inhibitor
Source data