General
Preferred name
TIOPRONIN
Synonyms
Tiopronine ()
Acadione ()
Captimer ()
Thiopronine ()
Thiola ()
Thiola ec ()
NSC-760416 ()
Tiopronin-d3 ()
P&D ID
PD000147
CAS
1953-02-2
1189700-74-0
Tags
available
drug
Approved by
FDA
First approval
1988
Drug Status
investigational
approved
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY Long-term carcinogenicity and mutagenicity studies have not been performed with tiopronin. In experimental animal studies, high doses of tiopronin were shown to interfere with the maintenance of pregnancy and viability of a fetus. No neural tube defects were detected when tiopronin was given to mice and rats in doses up to 10 times the highest recommended human dose. However, the manufacturer does not rule out the possibility of teratogenicity, as it has been seen with the drug d-penicillamine, which acts with a similar mechanism to tiopronin. Tiopronin is not recommended for use in breastfeeding mothers and has no established safety in children 9 years old or younger.; There have been case reports of tiopronin-related nephropathy.
Compound Sets
17
Cayman Chemical Bioactives
23720
33376
ChEMBL Approved Drugs
CHEMBL1314
ChEMBL Drugs
CHEMBL1314
DrugBank
DB06823
DrugBank Approved Drugs
DB06823
DrugCentral
2676
DrugCentral Approved Drugs
2676
DrugMatrix
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1314
MedChem Express Bioactive Compound Library
HY-B0373
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
C5W04GO61S
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
tiopronin-thiola
TargetMol Bioactive Compound Library
T1630
The Spectrum Collection
External IDs
34
Properties
(calculated by RDKit )
Molecular Weight
163.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.49
TPSA
66.4
Fraction CSP3
0.6
Chiral centers
1.0
Largest ring
0.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Target
ROS
Biosynthetic Origin
Other (Amino Acid)
Therapeutic Indication
Urolithiasis
Source data