General
Preferred name
TRIPTOLIDE
Synonyms
PG490 ()
NSC 163062 ()
TRIPTOLIDEN/A ()
Triptolide (PG490) ()
NSC-163062 ()
Triptolide-d3 ()
P&D ID
PD000121
CAS
144539-79-7
38748-32-2
Tags
available
drug candidate
Drug indication
infection
Autoimmune diabetes
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-¦ÊB activation inhibitor[1][2][3][4][5][6].
PRICE
115
DESCRIPTION
Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-??B activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities.
DESCRIPTION
Potent kynurenine 3-monooxygenase (KMO) inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
(Tocriscreen Plus)
DESCRIPTION
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii and has diverse biological activities. It has been used in trials studying the treatment of HIV, Crohn's Disease, Intestinal Diseases, Gastrointestinal Diseases, and Digestive System Diseases, among others.
(Enamine Bioactive Compounds)
DESCRIPTION
Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
42
Organisms
0
Compound Sets
19
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
EU-OPENSCREEN Bioactive Compound Library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
Tocriscreen Plus
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
360.16
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
7
Aromatic Ring Count
0
cLogP
1.1
TPSA
84.12
Fraction CSP3
0.85
Chiral centers
9.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
NF-¦ÊB
NF-??
Cytoskeletal Signaling
Metabolism
Target
Apoptosis
heat shock factor (HSF1)( in ALL cell lines)
MDM2
NF-κB
RELA
ADC Cytotoxin,Apoptosis related,HSP (HSP90),MDM2/MDMX,NF-¦ÊB
Primary Target
RNA/DNA Polymerase
Member status
virtual
MOA
"ERCC3 (TFIIH subunit)
Immunosuppressants
dCTP Pyrophosphatase 1 (DCTPP1) Inhibitors"
ERCC3 (TFIIH subunit)
dCTP Pyrophosphatase 1 (DCTPP1) Inhibitors
RNA polymerase inhibitor
Source data
