General
Preferred name
SUBERIC ACID
Synonyms
Octanedioic acid ()
OCTANEDIOATE ()
P&D ID
PD000120
CAS
70248-25-8
68937-72-4
505-48-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-¦Â and MAPK signaling pathways. Suberic acid inhibits skin dryness[1][2].
PRICE 29
DESCRIPTION Suberic acid (1,8-Octanedioic acid) is present in the urine of patients with fatty acid oxidation disorders. A metabolic breakdown product derived from oleic acid. Elevated levels of this unstaruated dicarboxylic acid are found in individuals with medium-chain acyl-CoA dehydrogenase deficiency (MCAD). Suberic acid is also associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency.
Compound Sets
3
MedChem Express Bioactive Compound Library
HY-W015300
Selleckchem Bioactive Compound Library
octanedioic-acid
The Spectrum Collection
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
174.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
0
Aromatic Ring Count
0
cLogP
1.5
TPSA
74.6
Fraction CSP3
0.75
Chiral centers
0.0
Largest ring
0.0
QED
0.57
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Akt
Endogenous Metabolite
p38 MAPK
TGF-β Receptor
TGF-¦Â Receptor
Pathway
MAPK/ERK Pathway
Metabolic Enzyme/Protease
PI3K/Akt/mTOR
TGF-beta/Smad
Source data