General
Preferred name
EBASTINE
Synonyms
Ebastel ()
LAS-W 090 ()
Ebastin ()
Kestine ()
RP64305 ()
LAS-W 090,RP64305 ()
RP-64305 ()
LAS-W-090 ()
RP 64305 ()
LAS W-090 ()
Ebastina ()
Ebastine-d5 ()
P&D ID
PD000095
CAS
90729-43-4
1216953-13-7
Tags
available
drug
First approval
1990
Drug indication
Irritable bowel syndrome
allergic disease
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ebastine (LAS-W 090) is an orally active, second-generation histamine H1 receptor antagonist. Ebastine can be used for the symptoms of allergic rhinitis and chronic idiopathic urticaria research[1].
PRICE 29
DESCRIPTION Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tissue without a central side effect, i. e not causing sedation or drowsiness. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
19
AdooQ Bioactive Compound Library
A14946
Cayman Chemical Bioactives
15372
30758
ChEMBL Approved Drugs
CHEMBL305660
ChEMBL Drugs
CHEMBL305660
Drug Repurposing Hub
DrugBank
DB11742
DrugBank Approved Drugs
DB11742
DrugCentral
977
DrugCentral Approved Drugs
977
DrugMAP
DMH21D9
DrugMatrix
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL305660
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
CHEMBL305660
MedChem Express Bioactive Compound Library
HY-B0674
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
ebastine
TargetMol Bioactive Compound Library
T2335
The Spectrum Collection
External IDs
41
Properties
(calculated by RDKit )
Molecular Weight
469.3
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
3
cLogP
7.22
TPSA
29.54
Fraction CSP3
0.41
Chiral centers
0.0
Largest ring
6.0
QED
0.31
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Indication
allergic rhinitis, urticaria
Target
CYP3A4, HRH1
Histamine Receptor
H1 receptor
MOA
Histamine Receptor antagonist
Source data