General
Preferred name
FLEROXACIN
Synonyms
AM-833 ()
Ro 23-6240 ()
RO 23-6240/000 ()
Megalone ()
Ro-236240 ()
Megalocin ()
RO-236240000 ()
RO-23-6240/000 ()
Fleroxacine ()
Fleroxacino ()
P&D ID
PD000090
CAS
79660-53-0
79660-72-3
Tags
available
drug
First approval
1992
Drug indication
bacterial disease
Bacterial infection
Drug Status
withdrawn
investigational
approved
experimental
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Fleroxacin is a fluoroquinolone compound with a broad-spectrum of antibacterial activity .
(GtoPdb)
PRICE
29
DESCRIPTION
Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone that strongly inhibits the DNA-supercoiling activity of DNA gyrase.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
369.13
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
1.7
TPSA
65.78
Fraction CSP3
0.41
Chiral centers
0.0
Largest ring
6.0
QED
0.89
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
DNA gyrase
Topo II
Topo IV
TOP2A
Indication
gonorrhea, enteritis, diarrhea, respiratory tract infections
Disease Area
infectious disease, gastroenterology
MOA
Topoisomerase inhibitor
Pathway
DNA Damage/DNA Repair
Microbiology/virology
Anti-infection
Therapeutic Class
Antiinfective Agents
Source data
