General
Preferred name
TACRINE HYDROCHLORIDE
Synonyms
9-Amino-1,2,3,4-tetrahydroacridine hydrochloride ()
Tacrine hydrochloride hydrate ()
Tacrine (hydrochloride) ()
Tacrine HCl ()
CI-970 ()
Alzyme ()
NSC-72108 ()
Cognex ()
P&D ID
PD000081
CAS
1684-40-8
Tags
available
drug
Drug Status
approved
Max Phase
4.0
First approval
1993
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cholinesterase inhibitor; reported to be useful ;in the treatment of Alzheimer's disease (LOPAC library)
DESCRIPTION Tacrine hydrochloride is a potent cholinesterase inhibitor used for the treatment of memory deficits in patients with Alzheimers's disease. Tacrine hydrochloride has been shown to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (IC50s = 31 and 26.5 nM, respectively). Tacrine also inhibits the uptake of serotonin and norepinephrine in rat cerebral cortex and reduces depolarization-induced calcium influx through L-type calcium channels in SN56 neuronal cells. (BOC Sciences Bioactive Compounds)
DESCRIPTION Cholinesterase inhibitor (Tocriscreen Total)
Cell lines
0
Organisms
1
Compound Sets
13
BOC Sciences Bioactive Compounds
tacrine-hydrochloride-cas-1684-40-8-item-204761
Cayman Chemical Bioactives
70240
ChEMBL Approved Drugs
CHEMBL1677
ChEMBL Drugs
CHEMBL1677
EU-OPENSCREEN Bioactive Compound Library
EOS102074
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1677
MedChem Express Bioactive Compound Library
HY-B1488
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
tacrine-hcl
The Spectrum Collection
Tocriscreen Total
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
234.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
2
cLogP
3.12
TPSA
38.91
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Cholinesterase
Target
Cholinesterase (ChE)
iGluR
AChR
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data