General
Preferred name
AMOXAPINE
Synonyms
CL-67772 ()
CL 67772,Asendin ()
Asendin ()
Defanyl ()
CL 67,772 ()
Asendis ()
NSC-759559 ()
CL 67772 ()
Amoxapina ()
CL-67,772 ()
P&D ID
PD000076
CAS
14028-44-5
Tags
available
drug
Approved by
FDA
First approval
1980
Drug indication
Major depressive disorder
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Amoxapine (CL-67772) is a norepinephrine reuptake blocker and a 5-HT2/5-HT3 antagonist. Amoxapine can be used for the research of depression. Amoxapine has antibacterial activity. Amoxapine can enhance the killing effect of macrophages on mycobacterium by inducing autophagy, while protecting the cells from death[1][2][3].
PRICE 29
DESCRIPTION Amoxapine is a dibenzoxazepine-derivative tricyclic antidepressant. (GtoPdb)
DESCRIPTION Amoxapine is a tetracyclic antidepressant of the dibenzoxazepine family with a wide range of pharmalogical effects. It is an agonist of 5-Hydroxytryptamine 2A, 2B, 2C receptors. It is used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. (Enamine Bioactive Compounds)
DESCRIPTION Tricyclic antidepressant; inhibits neuronal uptake of norepinephrine (LOPAC library)
DESCRIPTION Amoxapine (CL-67772) exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. Amoxapine is a tricyclic antidepressant of the dibenzoxazepine class. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
4
Compound Sets
31
Axon Medchem Screening Library
1333
Cayman Chemical Bioactives
17347
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1113
ChEMBL Drugs
CHEMBL1113
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00543
DrugBank Approved Drugs
DB00543
DrugCentral
191
DrugCentral Approved Drugs
191
DrugMAP
DMKITQE
DrugMAP Approved Drugs
DMKITQE
DrugMatrix
Enamine Bioactive Compounds
EBC-06994
Enamine BioReference Compounds
Guide to Pharmacology
201
Ki Database
AMOXAPINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1113
MedChem Express Bioactive Compound Library
HY-B0991
NCATS Inxight Approved Drugs
R63VQ857OT
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
amoxapine
TargetMol Bioactive Compound Library
T1568
The Spectrum Collection
ZINC Tool Compounds
ZINC000000000931
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
313.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
3.43
TPSA
36.86
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
7.0
QED
0.81
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
Uptake
MOA
norepinephrine transporter inhibitor
GlyT inhibitor
5-HT2A Antagonists
5-HT Reuptake Inhibitors
Norepinephrine Reuptake Inhibitors
norepinephrine reputake inhibitor
Target
Dopamine Receptor
Serotonin Transporter
Norepinephrine transporter
GlyT1b
GlyT2a
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, HRH1, HRH4, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR3A, HTR6, HTR7, SLC6A2, SLC6A3, SLC6A4
Tricyclic antidepressant
Autophagy
Bacterial
Amino acid transporter,GlyT
Member status
member
Indication
depression
Therapeutic Class
Antidepressants
Pathway
Anti-infection
Neuroscience
Source data