General
Preferred name
PHENOXYBENZAMINE HYDROCHLORIDE
Synonyms
CPD000058422 ()
NCI-c01661 ()
NSC 37448 ()
Phenoxybenzamine HCl ()
Phenoxybenzamine (hydrochloride) ()
NSC 37448, NCI-c01661 ()
DIBENYLINE ()
PHENOXYBENZAMINE CHLORIDE ()
DIBENZYLIN ()
DIBENZYLINE CHLORIDE ()
NSC-37448 ()
DIBENZYLINE HYDROCHLORIDE ()
DIBENZYLINE ()
DIBENZYRAN ()
PHENOXYBENZAMINE ()
P&D ID
PD000071
CAS
63-92-3
34238-85-2
59-96-1
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
adrenal gland pheochromocytoma
First approval
1953
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active ¦Á-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine hydrochloride also shows antitumor activity[1][2].
PRICE 29
DESCRIPTION Phenoxybenzamine HCl is a selective antagonist of alpha-adrenoceptor and calmodulin.It is used for the treatment of hypertension. (Enamine Bioactive Compounds)
DESCRIPTION Selective alpha adrenoceptor blocking agent; calmodulin antagonist (LOPAC library)
DESCRIPTION Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM. (BOC Sciences Bioactive Compounds)
DESCRIPTION Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
1
Compound Sets
17
AdooQ Bioactive Compound Library
A10719
Bioprocess diversity set
BOC Sciences Bioactive Compounds
phenoxybenzamine-hcl-cas-63-92-3-346569
Cayman Chemical Bioactives
16211
ChEMBL Approved Drugs
CHEMBL1200787
ChEMBL Drugs
CHEMBL1200787
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
EBC-06086
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
EUB0000906
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0431A
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Phenoxybenzamine-hydrochloride
TargetMol Bioactive Compound Library
T1158
The Spectrum Collection
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
339.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
4.62
TPSA
12.47
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha
Biological process
Resipration, oxidative phosphorylation, & mitochondrial targeting
Target
Adrenergic Receptor
CAM
α-adrenergic receptor
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Recommended Cell Concentration
10 uM
Source data