General
Preferred name
DIAZOXIDE
Synonyms
Diazoxidum ()
SRG-95213 ()
Sch-6783 ()
Proglycem ()
Sch-6783, SRG-95213, Proglycem ()
DIAZOXIDE CHOLINE ()
Diazoxido ()
SCH 6783 ()
Eudemine injection ()
Mutabase ()
Hyperstat ()
Eudimine ()
NSC-76130 ()
SRG 95213 ()
Hypertonalum ()
Eudemine ()
NSC-64198 ()
Diazoxide-d3 ()
P&D ID
PD000067
CAS
1098065-76-9
364-98-7
1432063-51-8
Tags
available
drug
drug candidate
Approved by
FDA
First approval
1973
Drug indication
Hypertriglyceridemia
Hypertension
Drug Status
approved
investigational
Max Phase
2.0
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Diazoxide is a potassium channel activator. Its mechanism of action revolves around enhancing cell membrane permeability to potassium ions. This action consequently elicits the relaxation of local smooth muscles. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.
DESCRIPTION Diazoxide is a potassium channel activator. (GtoPdb)
DESCRIPTION Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.
PRICE 29
DESCRIPTION Inhibits pacemaker (If) current (Tocris Bioactive Compound Library)
DESCRIPTION Blocks desensitization of AMPA receptors (Tocriscreen Plus)
DESCRIPTION Activator of ATP-dependent K+ channels in both vascular smooth muscle and pancreatic beta-cells; antihypertensive (LOPAC library)
DESCRIPTION Blocks desensitization of AMPA receptors (Tocriscreen Total)
DESCRIPTION Diazoxide is a non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions. (Enamine Bioactive Compounds)
DESCRIPTION Diazoxide (Proglycem) is a benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
1
Compound Sets
36
Cayman Chemical Bioactives
14576
29967
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL181
ChEMBL Drugs
CHEMBL181
CHEMBL4297276
Concise Guide to Pharmacology 2017/18
2409
Concise Guide to Pharmacology 2019/20
2409
Concise Guide to Pharmacology 2021/22
2409
Concise Guide to Pharmacology 2023/24
2409
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB01119
DrugBank Approved Drugs
DB01119
DrugCentral
854
DrugCentral Approved Drugs
854
DrugMAP
DML1538
DrugMAP Approved Drugs
DML1538
DrugMatrix
Enamine Bioactive Compounds
EBC-13327
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101657
Guide to Pharmacology
2409
Ki Database
diazoxide
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1140
NCATS Inxight Approved Drugs
O5CB12L4FN
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
diazoxide
TargetMol Bioactive Compound Library
T0126
The Spectrum Collection
Tocris Bioactive Compound Library
0964
Tocriscreen Plus
0964
Tocriscreen Total
External IDs
57
Properties
(calculated by RDKit )
Molecular Weight
229.99
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
1
cLogP
1.68
TPSA
58.53
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Selectivity
ATP-sensitive
MOA
thiazide sensitive sodium-chloride cotransporter inhibitor
Potassium Channel activator
K(ATP) Channel Activators
Target
Sodium/potassium-transporting ATPase subunit alpha-1
Potassium channel, inwardly rectifying, subfamily J, member 11
Potassium channel, inwardly rectifying, subfamily J, member 8
ATP1A1, CA1, CA2, KCNJ11, KCNJ8, KCNMA1, SLC12A3
Potassium Channel
ADC Cytotoxin,Potassium Channel
Na+/K+-ATPase
Primary Target
AMPA Receptors
Member status
member
Indication
hypoglycemia
Pathway
Autophagy
Membrane Transporter/Ion Channel
Therapeutic Class
Antihypertensive Agents
Source data