General
Preferred name
DOMPERIDONE
Synonyms
R33812 ()
Domperidone (monomaleate) ()
R33812 (monomaleate) ()
DEUDOMPERIDONE ()
Vivadone ()
Domperidona ()
NSC-299589 ()
Motilium 10 ()
R 33,812 ()
R-33812 ()
NSC-759575 ()
Motilium ()
Domilium ()
Evoxin ()
Motilium Instants ()
CIN-102 ()
Domperidone-d6 ()
P&D ID
PD000066
CAS
83898-65-1
57808-66-9
1329614-18-7
Tags
available
drug
drug candidate
First approval
1982
Drug indication
Gastroparesis
Relapsing-remitting multiple sclerosis
Gastrointestinal disease
Drug Status
vet_approved
approved
withdrawn
investigational
Max Phase
2.0
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Domperidone is an orally active, peripherally acting and selective antagonist of dopamine D2 and D3 receptors. (GtoPdb)
PRICE 29
DESCRIPTION Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].
DESCRIPTION Domperidone (R33812) monomaleate is an orally active and selective dopamine-2 receptor antagonist. Domperidone monomaleate acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].
DESCRIPTION Neurotoxic amino acid (Tocris Bioactive Compound Library)
DESCRIPTION Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic (LOPAC library)
DESCRIPTION Peripheral D2-like antagonist (Tocriscreen Total)
DESCRIPTION Domperidone (R33812)(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting (area postrema on the floor of the fourth ventricle and rhomboid fossa). (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
31
AdooQ Bioactive Compound Library
A10329
Cayman Chemical Bioactives
18875
30152
ChEMBL Drugs
CHEMBL219916
CHEMBL4594380
Concise Guide to Pharmacology 2017/18
965
Concise Guide to Pharmacology 2019/20
965
Concise Guide to Pharmacology 2021/22
965
Concise Guide to Pharmacology 2023/24
965
Drug Repurposing Hub
DrugBank
DB01184
DB19055
DrugBank Approved Drugs
DB01184
DrugCentral
945
DrugCentral Approved Drugs
945
DrugMAP
DMBDPY0
DrugMAP Approved Drugs
DMBDPY0
DrugMatrix
Guide to Pharmacology
965
Ki Database
DOMPERIDONE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL219916
Mcule NIBR MoA Box Subset
MCULE-4430288884
MedChem Express Bioactive Compound Library
HY-B0411
HY-B0411A
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Domperidone(Motilium)
TargetMol Bioactive Compound Library
T0082
The Spectrum Collection
Tocris Bioactive Compound Library
2536
Tocriscreen Total
Withdrawn 2.0
w36
External IDs
63
Properties
(calculated by RDKit )
Molecular Weight
425.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
4
cLogP
3.35
TPSA
78.82
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D2
Target
D3
dopamine
DRD2, DRD3
Dopamine Receptor
Primary Target
Non-selective Dopamine
MOA
Antagonist
Dopamine Receptor Antagonists
Dopamine Receptor antagonist
Member status
member
Indication
fescue toxicosis
ATC
A03FA03
Toxicity type
cardiovascular
Therapeutic Class
Antiemetics
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data