General
Preferred name
LOPERAMIDE HYDROCHLORIDE
Synonyms
R-18553 (hydrochloride) ()
Loperamide HCl ()
ADL 2-1294 ()
R-18553 (hydrochloride)Loperamide HCl ()
LOPERAMIDE ()
Loperamide HCl ()
Loperamide (hydrochloride) ()
ADL 2-1294,R-18553 hydrochloride ()
Loperagen ()
Gppe Pack ()
Diocaps ()
Imodium Instants ()
Imodium A-D Ez Chews ()
Imodium LiquiCaps ()
R 18,553 ()
Imodium IBS Relief ()
Imodium Classic ()
R-18553 ()
Diasorb ()
Diocalm ()
NSC-696356 ()
Diah-Limit ()
Diarrhoea Relief ()
Imodium A-D ()
Diareze ()
Entrocalm ()
Loperamidi hydrochloridum ()
Imodium ()
Diaquitte ()
Imodium Advanced ()
Lodiar ()
Imodium Instant Melts ()
Arret ()
Norimode ()
Dioraleze ()
Normaloe ()
P&D ID
PD000060
CAS
34552-83-5
137524-29-9
53179-11-6
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antiperistaltic
First approval
1976
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Meperidine congener which binds to opioid receptors; Ca2+ channel antagonist (LOPAC library)
DESCRIPTION Muscarinic agonist (Tocris Bioactive Compound Library)
DESCRIPTION Peripherally acting μ agonist. Also Ca2+ channel blocker (Tocriscreen Total)
Cell lines
0
Organisms
1
Compound Sets
17
Cayman Chemical Bioactives
14875
ChEMBL Approved Drugs
CHEMBL1707
ChEMBL Drugs
CHEMBL1707
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101675
EUbOPEN Chemogenomics Library
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1707
MedChem Express Bioactive Compound Library
HY-B0418A
NCATS Inxight Approved Drugs
77TI35393C
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Loperamide-hydrochloride
TargetMol Bioactive Compound Library
T0209
The Spectrum Collection
Tocris Bioactive Compound Library
0840
Tocriscreen Total
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
512.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
3
cLogP
5.51
TPSA
43.78
Fraction CSP3
0.34
Chiral centers
0.0
Largest ring
6.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
GPCR/G protein
Neuroscience
Autophagy
Neuronal Signaling
Target
??-opioid receptor
Opioid Receptor
Autophagy,Opioid Receptor
Primary Target
? Opioid Receptors
MOA
Agonist
Source data