General
Preferred name
PINACIDIL
Synonyms
PINACIDIL HYDRATE ()
S 1230 ()
P 1134 ()
S-1230 ()
P-1134 ()
P1134 ()
Pinacidil monohydrate ()
Pinacidil (monohydrate) ()
P-1134 (monohydrate) ()
(r,s)-pinacidil ()
PINACIDIL ANHYDROUS ()
Pindac ()
NSC-759588 ()
Pinacidil ()
Pinacidil (hydrate) ()
P&D ID
PD000054
CAS
85371-64-8
60560-33-0
113563-69-2
Tags
available
drug
Approved by
FDA
Drug indication
Hypertension
High blood pressure
Drug Status
approved
withdrawn
Max Phase
4.0
First approval
1989
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Pinacidil is a cyanoguanidine anti-hypertensive drug, which acts as an ATP-sensitive potassium channel opener in smooth muscle cells.
(GtoPdb)
DESCRIPTION
Pinacidil (P-1134) is a potent activator of ATP-sensitive potassium channel. Pinacidil is an antihypertensive agent hyperpolarizes vascular smooth muscle by opening K+ channels. Pinacidil enhances K+-efflux in smooth muscle. Pinacidil has vasorelaxant properties. Pinacidil is able to inhibit spontaneous tone and of reducing agonist induced contractions. Pinacidil can be studied in research area such as cardiovascular diseases[1][2].
PRICE
35
PRICE
29
DESCRIPTION
Pinacidil (P-1134) monohydrate is a potent activator of ATP-sensitive potassium channel. Pinacidil monohydrate is an antihypertensive agent hyperpolarizes vascular smooth muscle by opening K+ channels. Pinacidil monohydrate enhances K+-efflux in smooth muscle. Pinacidil monohydrate has vasorelaxant properties. Pinacidil monohydrate is able to inhibit spontaneous tone and of reducing agonist induced contractions. Pinacidil monohydrate can be studied in research area such as cardiovascular diseases[1][2].
DESCRIPTION
K+ channel activator; antihypertensive
(LOPAC library)
DESCRIPTION
Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure and peripheral resistance and producing fluid retention.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Pinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. The above processes result in reduced blood pressure.
(Enamine Bioactive Compounds)
DESCRIPTION
Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
3
Compound Sets
27
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
78
Molecular Weight
245.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
2.35
TPSA
73.1
Fraction CSP3
0.46
Chiral centers
1.0
Largest ring
6.0
QED
0.48
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
ATP-sensitive inward rectifier potassium channel opener
Target
Sulfonylurea receptor 2, Kir6.2
Potassium Channel
ATC
C
Therapeutic Class
Antihypertensive Agents
Pathway
Membrane Transporter/Ion Channel
Source data
