General
Preferred name
METOLAZONE
Synonyms
SR-720-22 ()
SR 720-22 ()
Mykrox ()
Zaroxolyn ()
Metozalone ()
Diulo ()
Normelan ()
Xuret ()
Metenix ()
Metazoline ()
Oldren ()
NSC-759581 ()
Metolazone-d7 ()
P&D ID
PD000048
CAS
17560-51-9
2714484-71-4
Tags
natural product
drug
available
Approved by
FDA
First approval
1973
Drug Status
approved
Drug indication
Diuretic
Hypertension
Antihypertensive
Edema
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Metolazone is a quinazoline thiazide-like and sulfonamide diuretic.
(GtoPdb)
DESCRIPTION
Inhibitor of thiazide-sensitive Na+/Cl- cotransporter; antihypertensive; moderate loop diuretic.
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
28
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
365.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
2.71
TPSA
92.5
Fraction CSP3
0.19
Chiral centers
1.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Na+/Cl- cotransporter
Target
Na+/Cl-symporter
Thrombin
Member status
virtual
MOA
Carbonic Anhydrase Type VII Inhibitors
Therapeutic Class
Antihypertensive Agents
Pathway
Metabolic Enzyme/Protease
Source data
