General
Preferred name
pentetrazol
Synonyms
PENTYLENETETRAZOL ()
Pentylenetetrazole ()
Pentylenetetrazole, Metrazole, pentetrazol, pentamethylenetetrazol, Corazol, Cardiazol, PTZ ()
Leptazole ()
Korazol ()
Cardiozol ()
Metrazol ()
Leptazol ()
NSC-5729 ()
Coranormol ()
Cenazol ()
Coryvet ()
Cardiazol ()
Metrazole ()
Corazole ()
NSC-66489 ()
Pentamethylenetetrazole ()
Korazole ()
P&D ID
PD000044
CAS
20192-24-9
54-95-5
Tags
available
drug
Drug Status
approved
withdrawn
experimental
investigational
Max Phase
2.0
Drug indication
respiratory system disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Pentylenetetrazol is a GABA(A) receptor antagonist, that displays activity as a central nervous system and respiratory stimulant.
DESCRIPTION Selective AMPA antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Non-specific CNS stimulant; convulsant (LOPAC library)
DESCRIPTION CNS stimulant (Tocriscreen Total)
Compound Sets
18
Cayman Chemical Bioactives
18682
ChEMBL Drugs
CHEMBL116943
Drug Repurposing Hub
DrugBank
DB13415
DrugCentral
3428
DrugCentral Approved Drugs
3428
DrugMatrix
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-7519359961
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
pentylenetetrazol
The Spectrum Collection
Tocris Bioactive Compound Library
2687
Tocriscreen Total
Withdrawn 2.0
w22
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
138.09
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
1
cLogP
0.4
TPSA
43.6
Fraction CSP3
0.83
Chiral centers
0.0
Largest ring
7.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
CNS
Primary Target
Miscellaneous GABA
Member status
virtual
MOA
GABA(A) Receptor Antagonists
GABA Receptor antagonist
ATC
R07AB53
Toxicity type
neurological
Target
GABA Receptor
Source data