General
Preferred name
MS049
Synonyms
MS049 2HCl (1502816-23-0(free base)) ()
MS049 hydrochloride ()
MS049 (hydrochloride) ()
P&D ID
PD000035
CAS
1502816-23-0
2095432-59-8
Tags
available
probe
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Orthogonal probes
6
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
55
DESCRIPTION
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 ??M for PRMT1, PRMT3, and PRMT8, respectively) and displays no inhibition against type II or type III PRMTs nor any additional methyltransferases or nonepigenetic targets tested.
DESCRIPTION
MS049 is a potent and selective dual inhibitor of PRMT4 and PRMT6 , developed in a collaboration between the Structural Genomics Consortium and the Icahn School of Medicine at Mount Sinai. It is active in cellular assays. It is one of the chemical tools in the SGC's Epigenetic Probes Collection.
(GtoPdb)
DESCRIPTION
MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells[1].
PRICE
46
DESCRIPTION
MS049 is a potent and selective PRMT4 and PRMT6 inhibitor. MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 µM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
MS049 is a potent and selective PRMT4 and PRMT6 inhibitor. MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 µM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
BOC Sciences Bioactive Compounds
CZ-OPENSCREEN Bioactive Library
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
High-quality chemical probes
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
Protein methyltransferases chemical toolbox
Selleckchem Bioactive Compound Library
SGC Probes
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
248.19
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
1.89
TPSA
24.5
Fraction CSP3
0.6
Chiral centers
0.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Histone methyltransferase
PRMT4
PRMT6
Histone Methyltransferase,PRMT
CARM1
Member status
member
MOA
PRMT4/6 inhibitor
PRMT4 and PRMT6 inhibitor
Pathway
Epigenetics
Chromatin/Epigenetic
Protein Family
Histone Methyltransferase
Recommended Cell Concentration
1 uM
Source data
