General
Preferred name
bromosporine
Synonyms
P&D ID
PD000022
CAS
1619994-69-2
Tags
available
probe
Probe info
Probe type
experimental probe
Probe sources
High-quality chemical probes
SGC Probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Bromosporine is a broad spectrum inhibitor of bromodomain-containing proteins. This is contained in the Structural Genomics Consortium's (SGC) Epigenetics Probes Collection. (GtoPdb)
DESCRIPTION Bromosporine is a potent BET inhibitor with an IC50 value of 2.1 ¦ÌM for PCAF. Bromosporine can arrest cell cycle and induce apoptosis in cancer cells. Bromosporine exhibits excellent antitumor activity in xenograft mice model when combined with 5-FU (HY-90006). Bromosporine can increase CDK9 T-loop phosphorylation in HIV-1 latency models, resulting the protection of reactivate HIV-1 replication from latency. Bromosporine can be used to research colorectal cancer, acute myeloid leukemia (AML) and AIDS[1][2][3][4].
PRICE 154
DESCRIPTION Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 ??M), respectively.
DESCRIPTION Broad spectrum bromodomain inhibitor (Tocriscreen Plus)
DESCRIPTION Mcl-1 inhibitor; proapoptotic (Tocris Bioactive Compound Library)
DESCRIPTION Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively. (TargetMol Bioactive Compound Library)
Cell lines
6
Organisms
0
Compound Sets
12
AdooQ Bioactive Compound Library
A13163
Cayman Chemical Bioactives
14119
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
Guide to Pharmacology
8234
High-quality chemical probes
PD000022
MedChem Express Bioactive Compound Library
HY-15815
Selleckchem Bioactive Compound Library
bromosporine
SGC Probes
Bromosporine
TargetMol Bioactive Compound Library
T6255
Tocris Bioactive Compound Library
4758
Tocriscreen Plus
4758
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
404.13
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
2.35
TPSA
127.58
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Target
BRD2
BRD4
BRD9
CECR2
Epigenetic Reader Domain
Apoptosis
CDK
HIV
BRD3
BRDT
Primary Target
Bromodomains
MOA
Inhibitor
Bromodomain inhibitor
Pathway
Cell Cycle/Checkpoint
Chromatin/Epigenetic
Anti-infection
Cell Cycle/DNA Damage
Epigenetics
Source data