General
Preferred name
IOX2
Synonyms
IOX 2 ()
JICL38 ()
P&D ID
PD000008
CAS
931398-72-0
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
IOX2 is a selective, cell permeable inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylase protein PHD2. This is a compound from the Structural Genomics Consortium's (SGC) Epigenetics Probes Collection.
(GtoPdb)
DESCRIPTION
IOX2 is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 regulates platelet function and arterial thrombosis by upregulating HIF-1¦Á expression and inhibiting ROS production. IOX2 can be used in the study of thrombotic diseases[1][2].
PRICE
76
MOA
Inhibitor
(Chemical Probes.org)
DESCRIPTION
Potent B-Raf inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent, selective HIF-1alpha prolyl hydroxylase-2 (PHD2) inhibitor
(Tocriscreen Plus)
DESCRIPTION
IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
22
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
Chemical Probes.org
Concise Guide to Pharmacology 2017/18
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
High-quality chemical probes
JUMP-MOA Compound Set
LINCS compound set
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
SGC Probes
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Welcome Trust Cancer Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
352.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
1.57
TPSA
108.63
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
EGLN1
HIF/HIF Prolyl-Hydroxylase
PHD2
EGLN1, KDM2A, KDM5C
PHD inhibitor
HIF
Primary Target
Hydroxylases
MOA
Inhibitor
EGLN1 inhibitor
EGLN1 gene inhibitor
"EGLN1 inhibitor
EGLN1 gene inhibitor"
hypoxia inducible factor inhibitor
Member status
member
Pathway
Chromatin/Epigenetic
Metabolism
Metabolic Enzyme/Protease
Protein Family
2OG
Target class
Enzyme
Target subclass
Hydrolase
Recommended Cell Concentration
1 uM
Source data
