General
Preferred name
Andropanolide
Synonyms
ANDROGRAPHOLIDE ()
P&D ID
PD069769
CAS
5508-58-7
869807-57-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages[1].
PRICE 462
DESCRIPTION Andropanolide is a dipterocarbon from Andrographis paniculata with anti-HIV, antimalarial and anticancer activities and inhibits Lipopolysaccharides (LPS)-stimulated overproduction of nitric oxide (NO) in RAW264.7 macrophages.
DESCRIPTION Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist (Tocris Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
2
MedChem Express Bioactive Compound Library
HY-N1912
Tocris Bioactive Compound Library
4626
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
350.21
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
0
cLogP
1.96
TPSA
86.99
Fraction CSP3
0.75
Chiral centers
6.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
Primary Target
NF-?B and I?B
MOA
Inhibitor
Source data