General
Preferred name
DPAT
Synonyms
(±)-8-Hydroxy-DPAT hydrobromide ()
8-Hydroxy-DPAT hydrobromide ()
S(-)-8-HYDROXY-DPAT ()
8-hydroxy-DPAT ()
(R)-(+)-8-HYDROXY-DPAT ()
8-OH-DPAT,(-) ()
8-OH-DPAT,(+) ()
8-OH-DPAT ()
[3H]8-OH-DPAT ()
8-OH-DPAT (hydrobromide) ()
8-Hydroxy-DPAT (hydrobromide) ()
8-OH-DPAT (8-Hydroxy-DPAT) ()
[3H]8-OH-DPAT ()
P&D ID
PD047959
CAS
78950-78-4
76135-31-4
87394-87-4
105558-30-3
Tags
drug candidate
natural product
probe
biased GPCR ligand
available
Drug indication
Discovery agent
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
High-quality chemical probes
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective 5-HT1A serotonin receptor agonist (LOPAC library)
DESCRIPTION Highly selective alpha1 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Selective 5-HT1A agonist. Also has moderate affinity for 5-HT7 (Tocriscreen Total)
DESCRIPTION 8-OH-DPAT (8-Hydroxy-DPAT) is an agonist that has selectivity for 5-HT1A receptor (pIC50 = 8.19). It was subsequently found to be a serotonin reuptake inhibitor and a 5-HT7 receptor agonist as well. Studies showed that it exhibited antidepressant, anxiolytic and other properties. (BOC Sciences Bioactive Compounds)
DESCRIPTION 8-Hydroxy-DPAT hydrobromide is a selective 5-HT1A agonist with moderate affinity for 5-HT7 receptors (pKi = 6.6 at the human 5-HT7 receptor expressed in HEK 293 cells). (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
1
Compound Sets
22
Axon Medchem Screening Library
1015
BiasDB
8-OH-DPAT
BOC Sciences Bioactive Compounds
8-hydroxy-dpat-hydrobromide-cas-76135-31-4-347619
8-oh-dpat-cas-78950-78-4-item-134424
Concise Guide to Pharmacology 2017/18
31
7
Concise Guide to Pharmacology 2019/20
31
7
Concise Guide to Pharmacology 2021/22
31
7
Concise Guide to Pharmacology 2023/24
31
7
DrugMAP
DM4KCYU
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS101650
Guide to Pharmacology
31
7
High-quality chemical probes
PD047959
Ki Database
8-OH-DPAT
8-OH-DPAT,(+)
8-OH-DPAT,(-)
DPAT
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-7091667929
MedChem Express Bioactive Compound Library
HY-15688
HY-112061
Novartis Chemogenetic Library (NIBR MoA Box)
Probe Miner (suitable probes)
P08908/1063701
Selleckchem Bioactive Compound Library
8-oh-dpat-8-hydroxy-dpat
TargetMol Bioactive Compound Library
T4305
Tocris Bioactive Compound Library
0529
Tocriscreen Total
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
247.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
3.37
TPSA
23.47
Fraction CSP3
0.62
Chiral centers
1.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
5-HT1A
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Target
5-HT1A,5-HT7
5-HT1A agonist
5-HT Receptor
Primary Target
5-HT1A Receptors
MOA
Agonist
alpha-Adrenoceptor Antagonists
Member status
virtual
Solubility
DMSO Solubility: 49 mg/mL (198.07 mM)
Source data