General
Preferred name
PTP inhibitor 1
Synonyms
PTP Inhibitor II ()
NSC 129010, 4-(Bromoacetyl)anisole ()
P&D ID
PD043997
CAS
2632-13-5
Tags
covalent binder
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PTP inhibitor 1 is a protein tyrosine phosphatase (PTP) inhibitor, with anti-angiogenic effect[1].
PRICE 29
DESCRIPTION PTP inhibitor 1 is an inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(??SH2)),with Ki of128 ??M.
DESCRIPTION PTP inhibitor 1 is a protein tyrosine phosphatase inhibitor, with anti-angiogenic effect. (Enamine Bioactive Compounds)
DESCRIPTION PTP inhibitor 1 is an inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)),with Ki of128 μM. (TargetMol Bioactive Compound Library)
Compound Sets
6
Cayman Chemical Bioactives
20629
CovalentInDB
CI000010
Enamine Bioactive Compounds
EBC-153080
MedChem Express Bioactive Compound Library
HY-W013478
Selleckchem Bioactive Compound Library
ptp-inhibitor-2
TargetMol Bioactive Compound Library
T7541
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
227.98
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
2.27
TPSA
26.3
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
phosphatase
protein tyrosine phosphatase(PTP)
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data