General
Preferred name
MYRIOCIN
Synonyms
Thermozymocidin ()
ISP-I ()
P&D ID
PD020872
CAS
35891-70-4
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 55
DESCRIPTION Myriocin (Thermozymocidin), a metabolite derived from Myriococcum albomyces, is a serine-palmitoyltransferase (SPT) inhibitor with potential antitumour, anticancer, and antiparasitic activities.Myriocin inhibits tumour growth by regulating macrophage polarisation and function through the PI3K/Akt/mTOR pathway.Myriocin inhibits HCV infection and can be used in the study of neurological diseases. Myriocin inhibits HCV infection and can be used to study neuropathy and fungal infections.
DESCRIPTION Myriocin is a sphingosine-like potent immunosuppressant acting primarily via inhibition of serine palmitoyltransferase which catalyses the first step of sphingolipid biosynthesis . The compound was originally isolated from the fungus Isaria sinclarii. (GtoPdb)
Cell lines
0
Organisms
1
Compound Sets
8
Cayman Chemical Bioactives
63150
Concise Guide to Pharmacology 2017/18
6664
Concise Guide to Pharmacology 2019/20
6664
Concise Guide to Pharmacology 2021/22
6664
Concise Guide to Pharmacology 2023/24
6664
DrugMAP
DMVXW4L
Guide to Pharmacology
6664
MedChem Express Bioactive Compound Library
HY-N6798
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
401.28
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
5
Rotatable Bonds
18
Ring Count
0
Aromatic Ring Count
0
cLogP
2.31
TPSA
141.08
Fraction CSP3
0.81
Chiral centers
3.0
Largest ring
0.0
QED
0.18
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
HCV
Pathway
Anti-infection
Source data