General
Preferred name
AM630
Synonyms
AM 630 ()
Iodopravadoline ()
AM-630 ()
6-Iodopravadoline (AM630) ()
6-Iodopravadoline ()
P&D ID
PD016668
CAS
164178-33-0
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
97
DESCRIPTION
CB2 selective antagonist/inverse agonist
(Tocriscreen Total)
DESCRIPTION
6-Iodopravadoline (AM630) is an antagonist of CB2 (Ki: 31.2 nM). And it shows 165-fold selectivity more than CB1 receptors.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
17
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
Ki Database
Mcule NIBR MoA Box Subset
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
504.09
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
4.13
TPSA
43.7
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CB
CB2
CNR1, CNR2
CB2 antagonist
Cannabinoid Receptor
Pathway
Neuronal Signaling
GPCR/G protein
Member status
virtual
MOA
CNR2 antagonist
Cannabinoid Receptor antagonist
Source data
