General
Preferred name
GRANISETRON
Synonyms
Granisetron??Hydrochloride ()
Sancuso, Kevatril, Granisetronum, Sustol ()
Granisetron (hydrochloride) ()
Granisetron-d3 ()
P&D ID
PD013356
CAS
109889-09-0
107007-99-8
1224925-76-1
Tags
available
drug
Approved by
EMA
PMDA
FDA
First approval
1993
Drug Status
approved
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Granisetron is a serotonin 5-HT3 receptor antagonist. It is used as an antiemetic to treat nausea and vomiting following chemotherapy.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
312.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
2.32
TPSA
50.16
Fraction CSP3
0.56
Chiral centers
3.0
Largest ring
6.0
QED
0.93
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
5-HT Receptor antagonist
serotonin receptor antagonist
Indication
nausea, vomiting
Target
HTR3A
5-HT Receptor
Source data
