General
Preferred name
IWR-1-endo
Synonyms
endo-IWR 1 ()
IWR-1 ()
P&D ID
PD012999
CAS
1127442-82-3
Tags
available
obsolete probe
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
IWR-1 is a tankyrase inhibitor which inhibits Wnt/¦Â-catenin signaling pathway.
DESCRIPTION
beta-catenin binder; inhibits Wnt signaling
(Tocris Bioactive Compound Library)
DESCRIPTION
Wnt/beta-catenin signaling inhibitor; axin stabilizer
(Tocriscreen Plus)
DESCRIPTION
Axin stabilizer; promotes β-catenin phosphorylation
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
0
Compound Sets
11
Axon Medchem Screening Library
Cayman Chemical Bioactives
Drug Repurposing Hub
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Obsolete Compounds
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
409.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
6
Aromatic Ring Count
3
cLogP
3.8
TPSA
79.37
Fraction CSP3
0.2
Chiral centers
4.0
Largest ring
6.0
QED
0.53
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target
Organoid
Wnt
TNKS, TNKS2
Wnt/TNKS inhibitor
Target Type
Cell Biology
Primary Target
?-catenin
Member status
member
MOA
Wnt Signaling Inhibitors
PARP inhibitor
Pathway
Stem Cell/Wnt
Source data
