General
Preferred name
KETAZOLAM
Synonyms
Ansieten ()
NSC-338158 ()
U-28,774 ()
Contamex ()
U-28774 ()
Anseren ()
Loftran ()
Anxon ()
Unakalm ()
P&D ID
PD009467
CAS
27223-35-4
Tags
available
drug
Drug Status
approved
investigational
Max Phase
2.0
Drug indication
Anxiety
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Benzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA), which results in sedative, hypnotic, anxiolytic, anticonvulsant, muscle relaxant and amnesic action.; Benzodiazepines bind nonspecifically to benzodiazepine receptors which mediate sleep, affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
METABOLISM Ketazolam is metabolized to diazepam, followed by demoxepam, and finally desmethyldiazepam.
Compound Sets
8
Cayman Chemical Bioactives
11449
ChEMBL Drugs
CHEMBL2104356
DrugBank
DB01587
DrugBank Approved Drugs
DB01587
DrugCentral
1525
DrugCentral Approved Drugs
1525
DrugMatrix
ReFrame library
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
368.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
2
cLogP
3.28
TPSA
49.85
Fraction CSP3
0.2
Chiral centers
1.0
Largest ring
7.0
QED
0.78
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data