General
Preferred name
FENSPIRIDE
Synonyms
FENSPIRIDE HYDROCHLORIDE ()
1-Oxa-3,8-diazaspiro(4.5)decan-2-one, 8-(2-phenylethyl)- ()
Fenspiride HCl ()
Decaspiride ()
Fluiden ()
Pneumorel ()
Fenspiride (Hydrochloride) ()
NAT-333 ()
NSC-757825 ()
NDR-5998A ()
Fenspirida ()
Eurespal ()
Fenspiride-d5 ()
P&D ID
PD009425
CAS
5053-08-7
5053-06-5
1246911-67-0
Tags
available
drug candidate
drug
Drug Status
approved
experimental
withdrawn
Drug indication
Anti-Adrenergic (alpha-receptor)
Bronchodilator
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
alpha-Adrenoceptor antagonist; NSAID
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
18
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
Enamine BioReference Compounds
LOPAC library
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
260.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
1
cLogP
1.8
TPSA
41.57
Fraction CSP3
0.53
Chiral centers
0.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha
Pathway
Metabolism
GPCR/G protein
Immunology/Inflammation
Metabolic Enzyme/Protease
Neuronal Signaling
Target
PDE3
PDE4
Histamine Receptor
Phosphodiesterase (PDE)
PDE
Indication
asthma, otitis, sinusitis, rhinopharyngitis, laryngitis
Disease Area
pulmonary, otolaryngology
MOA
bronchodilator
ATC
R03BX01
R03DX03
Toxicity type
NULL
Source data
