General
Preferred name
FLUTAMIDE
Synonyms
SCH 13521 ()
FLUTAMIDE13311-84-7 ()
SCH-13521 ()
Eulexin ()
NSC-215876 ()
Chimax ()
Drogenil ()
Flutamide-d7 ()
P&D ID
PD001517
CAS
13311-84-7
337962-98-8
223134-72-3
Tags
available
prodrug
drug
Approved by
FDA
First approval
1989
Drug Status
investigational
approved
Drug indication
Prostate cancer
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Flutamide is an androgen receptor antagonist. (GtoPdb)
DESCRIPTION PPARalpha agonist (Tocris Bioactive Compound Library)
DESCRIPTION Non-steroidal androgen receptor antagonist (Tocriscreen Plus)
DESCRIPTION Non-steroidal anti-androgen (LOPAC library)
Cell lines
7
Organisms
2
Compound Sets
35
AdooQ Bioactive Compound Library
A10402
Cayman Chemical Bioactives
20359
33541
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL806
ChEMBL Drugs
CHEMBL806
Concise Guide to Pharmacology 2017/18
6943
Concise Guide to Pharmacology 2019/20
6943
Concise Guide to Pharmacology 2021/22
6943
Concise Guide to Pharmacology 2023/24
6943
Drug Repurposing Hub
DrugBank
DB00499
DrugBank Approved Drugs
DB00499
DrugCentral
1223
DrugCentral Approved Drugs
1223
DrugMAP
DMK0O7U
DrugMAP Approved Drugs
DMK0O7U
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
6943
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL806
Mcule NIBR MoA Box Subset
MCULE-7498839065
MedChem Express Bioactive Compound Library
HY-B0022
NCATS Inxight Approved Drugs
76W6J0943E
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FIM1B4XSSB8
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Flutamide(Eulexin)
TargetMol Bioactive Compound Library
T0489
The Spectrum Collection
Tocris Bioactive Compound Library
4094
Tocriscreen Plus
4094
External IDs
42
Properties
(calculated by RDKit )
Molecular Weight
276.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
3.21
TPSA
72.24
Fraction CSP3
0.36
Chiral centers
0.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Selectivity
Androgen
MOA
Androgen Receptor antagonist
Antagonist
Androgen Receptor Antagonists
Target
Androgen Receptor
AHR, AR
Pathway
Endocrinology/Hormones
Vitamin D Related/Nuclear Receptor
Primary Target
Androgen Receptors
Member status
member
Indication
prostate cancer
Therapeutic Class
Anticancer Agents
Source data