General
Preferred name
(S)-10-Hydroxycamptothecin
Synonyms
10-HYDROXYCAMPTOTHECIN ()
10-HCPT ()
10-Hydroxycamptothecin, Hydroxycamptothecine ()
Hydroxy Camptothecine ()
HYDROXYCAMPTOTHECIN ()
(S)-10-hydroxy-Camptothecin ()
10-Hydroxy Camptothecin ()
10-Hydroxycamptothecin ()
10-Hydroxy-Camptothecin ()
10-Hydroxycamptothecine ()
Irinotecan related compound a ()
NSC-107124 ()
P&D ID
PD001274
CAS
19685-09-7
64439-81-2
Tags
available
drug candidate
Drug indication
Discovery agent
Hepatocellular carcinoma
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment[1][2][3][4].
DESCRIPTION
(S)-10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor with potent anti-tumor activity.
(Enamine Bioactive Compounds)
DESCRIPTION
(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor used as a clinical therapeutic agent against hepatoma.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
32
Organisms
0
Compound Sets
11
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
Enamine Bioactive Compounds
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
364.11
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
5
Aromatic Ring Count
3
cLogP
1.79
TPSA
101.65
Fraction CSP3
0.25
Chiral centers
1.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Topo I
Topoisomerase
TOP1
MOA
Topoisomerase inhibitor
Pathway
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Source data
