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&
Drugs
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89
compound sets
129,831
original compounds
114,806
standardized compounds
100,371
nonisomeric compounds
11,775
targets
294,544
compound-target associations
2,865
pathways
6,074
target/pathway classes
515
structural alerts
9,286
matched structural alerts
∞
filter combinations
Probes
&
Drugs
01.2024
COMPOUNDS
APPROVED DRUGS
PROBES
PROBE
TYPES
1,244
experimental
3,670
calculated
1,123
P&D approved
790
high-quality
253
obsolete
183
free of charge
probe
P&D approved
Glucocorticoid receptor
Kinase
similar to Imatinib
nuisance compounds
The Probes & Drugs portal (P&D)
is a hub for the integration of high-quality bioactive compound sets enabling their analysis and comparison. Its main focus is on
chemical probes
and
drugs
but it also includes additional relevant sets from specialist databases/scientific publications, and vendor sets. Upon these, established bioactive chemistry sources (such as
ChEMBL
,
BindingDB
,
Guide To Pharmacology
,
DrugCentral
or
DrugBank
) are utilized for compounds' biological annotation. As of
ver. 01.2024
, the P&D compound database is composed of
89 sources
including
13 probe-related
,
12 drug compilations
,
45 academic/non-commercial sets
and
16 precompiled sets from bioactive compound vendors
.
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FAQ
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Examples of complex queries
1
What chemical probes are also approved drugs?
2
Which approved drugs bind to Glucocorticoid and Mineralocrticoid receptor with at least 1 nM potency?
3
What potent GPCR ligands are also potent Kinase ligands?
4
What chemical probes are highly-rated at the Chemical Probes Portal as well as Probes & Drugs?
5
What is the intersection of compounds in DrugBank, DrugCentral and ChEMBL Approved Drugs set?
6
What chemical probes are associated with at least one structural alert (PAINS, nuisance compounds, obsolete structure)?
7
What potent ligands of Estrogen receptor α are dissimilar to Estradiol?
8
What chemical probes are, based on available data, meeting the biochemical potency (100nM) and on target cell-based potency (1µM) criteria?
Latest news
Feb. 13, 2024
First P&D release in 2024 with the new Concise guide to pharmacology, Withdrawn DB and a glossary
The first release of the Probes & Drugs this year - 01.2024 - is here...
(read more)
Oct. 9, 2023
P&D 02.2023 is out with probe controls set, highlighted selectivity and target family distribution
The second version of the Probes & Drugs portal this year - 02.2023 - was...
(read more)
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